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From New York City - George Washington Bridge to I-80. In PA, exit from I-80 at EXIT 158 (Milesburg/Altoona). Merge onto Appalacian Trailway. Turn Slight Left onto I-99 S / US-220 S / PA-350 S / Appalacian Trailway / Bud Shuster Highway Continue to follow I-99 S / US-220 S.
From Philadelphia - Take Route 76 W toward Valley Forge. Then take US-220 / I-99 Exit 146 toward Bedford - Altoona / Johnstown. Turn Left onto US-220 BR. Merge onto I-99 N / US-220 N via the ramp on the Left.
From Pittsburgh - Merge onto I-376 E / US-22 E toward Monroeville. Merge onto US-22 E / William Penn Highway via the exit on the Left toward Murrysville. Merge onto I-99 N / US-220 N via the exit on the Left toward Altoona.
From Washington D.C. - Take I-395 S. Take EXIT 10C toward Arlington Cemetery (Crossing into Virgina). Merge onto George Washington Memorial Parkway N / GW Parkway N (Passing through District OF Columbia- then crossing into Virgina). Merge onto I-495 N / Capital Beltway toward Maryland (Crossing into Maryland). Keep Left to take I-270 Spur N via Exit 38 toward Rockville / Frederick. I-270 Spur N becomes I-270 N. Merge onto I-70 W via Exit 32 toward Hagerstown (Crossing into Pennsylvania). Take the US-30 E / I-70 W exit toward Harrisnurg / Mcconnellsburg / New Stanton / Pennsylvania Turnpike. Turn Slight Right onto I-70 / US-30 / Lincoln Highway. Merge onto I-70 W toward I-76 / Pennsylvania Turnpike / Pittsburg / Harrisburg. Take the US-220 / I-99 exit- EXIT 146- toward Bedford-Altoona / Johnstown. Turn Left onto US-220 BR. Merge onto I-99 N / US-220 N via the ramp on the Left.